General Information

  • ID:  hor007214
  • Uniprot ID:  Q8IVG9(2-24)
  • Protein name:  Humanin
  • Gene name:  NA
  • Organism:  Homo sapiens
  • Family:  Humanin family
  • Source:  Human
  • Expression:  Expressed in testis; seminal plasma and sperm (at protein level) (PubMed-20542501; PubMed-30920769). Higher seminal plasma levels are associated with normospermia than with oligospermia; asthenospermi
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
  • GO MF:  GO:0005737 cytoplasm; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005739 mitochondrion; GO:0005634 nucleus; GO:0048471 perinuclear region of cytoplasm; GO:0036126 sperm flagellum; GO:0097225 sperm midpiece
  • GO BP:  GO:0042802 identical protein binding; GO:0001664 G protein-coupled receptor binding; GO:0005102 signaling receptor binding; GO:0048019 receptor antagonist activity
  • GO CC:  GO:1900118 negative regulation of execution phase of apoptosis; GO:0097435 supramolecular fiber organization; GO:0032692 negative regulation of interleukin-1 production; GO:0032701 negative regulation of interleukin-18 production; GO:0050728 negative regulation of inflammatory response; GO:1902883 negative regulation of response to oxidative stress; GO:1904646 cellular response to amyloid-beta; GO:0043524 negative regulation of neuron apoptotic process; GO:0006915 apoptotic process; GO:0007267 cell-cell signaling; GO:0150079 negative regulation of neuroinflammatory response; GO:0006879 intracellular iron ion homeostasis; GO:0030595 leukocyte chemotaxis; GO:0007005 mitochondrion organization; GO:1905907 negative regulation of amyloid fibril formation; GO:1900226 negative regulation of NLRP3 inflammasome complex assembly; GO:0043066 negative regulation of apoptotic process

Sequence Information

  • Sequence:  APRGFSCLLLLTSEIDLPVKRRA
  • Length:  23
  • Propeptide:  MAPRGFSCLLLLTSEIDLPVKRRA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    NA

Physical Information

Mass: Formula:
Absent amino acids: Common amino acids:
pI: Basic residues:
Polar residues: Hydrophobic residues:
Hydrophobicity: Boman Index:
Half-Life: Half-Life Yeast:
Half-Life E.Coli: Aliphatic Index
Instability Index: Extinction Coefficient cystines:
Absorbance 280nm:

Literature

  • PubMed ID:  NA
  • Title:  NA